![]() ![]() ![]() An assessment of clinical blood parameters in patients with severe COVID-19 disease (requiring intensive care), patients with nonsevere disease (not requiring intensive care), general medical in-patients without COVID-19, and healthy donors was undertaken. Therefore, we assessed clinical platelet parameters and circulating platelet activity in patients with severe and nonsevere COVID-19. Although high rates of venous thromboembolism and evidence of COVID-19-induced endothelial dysfunction have been reported, the precise aetiology of the increased thrombotic risk associated with COVID-19 infection remains to be fully elucidated. It is necessary to understand better how platelet dysfunction occurs and combat it in COVID-19 to limit the number of deaths caused by a progressing illness.Ĭoronavirus Disease 2019 (COVID-19), caused by the novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), has affected over 30 million globally to date. The cause of COVID-19's hypercoagulability is likely multifaceted, but the inflammatory response that develops due to the infection is assumed to be the primary driving force. Furthermore, the higher MPV at the time of admission in patients who developed severe disease demonstrates that platelets with higher granule density express higher levels of activation markers. Increased MPV and IPF may develop even in persons with normal platelet counts who have COVID-19 because of the significant compensatory response that occurs during this illness. According to the research that has been done so far on the issue, COVID-19 coagulopathy is thought to be caused by a combination of pulmonary platelet consumption, low-grade disseminated intravascular hemorrhage, and thrombotic microangiopathy. Patients with stroke6 and acute myocardial infarction had higher mean platelet volume (MPV) levels than control persons. Adenosine diphosphate (ADP), collagen, and adrenaline increase the aggregation and secretion of big platelets, making them more reactive and producing more prothrombotic factors, including thromboxane A2 (TxA2). Mean platelet volume (MPV) is an important laboratory metric for the function of platelets. ![]()
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